Ferrocene-based unsymmetrical bis phosphines, Fc (PAd2)(PR2) (R= Ph, Cy, iPr and tBu) abbreviated as MPhos ligands, as well as their corresponding (MPhos)PdCl2 complexes as pre-catalysts were developed in very good yields and fully characterized. These complexes as precatalysts were effectively utilized for many Csp2-Csp3 cross-coupling reactions such as Murahashi-Feringa, Kumada-Corriu, Negishi and Suzuki-Miyaura for model and “drug-like” substrates to demonstrate their potential applications in API synthesis. The details of the design of the catalysts and their applications in organic synthesis will be presented. Audience Take Away
They can understand the latest development in cross coupling the most active area in homogenous catalysis.
Apply the principles in organic synthesis for pharmaceutical, electronics and agrochemicals applications both in academia and industry.
Yes, of course. Sp2-sp3 coupling one of the underdeveloped areas in cross coupling
Will it improve the accuracy of a design, or provide new information to assist in a design problem? Yes.
These catluarts are now commercially available through MilliporeSigma (Merck KGaA, Darmstadt, Germany)
Biography:
Thomas J. Colacot joined MilliporeSigma (a business of Merck KGaA, Darmstadt, Germany) in 2018 as an R&D Fellow and Director of Global Technology Innovation, Life Science Business, in Milwaukee, WI. He has extensive experience in developing new and innovative products and technology with a very strong track record of commercialization globally and is considered an industrial expert in organometallics and homogeneous catalysis in organic synthesis. He has over 120 peer-reviewed publications and over 65 patents internationally. Thomas is a recipient of many awards and honors, including the 2021 Scientific Curriculum Vitae (Life Time Achievement Award) from the Chairman of the Board and CEO of Merck KGaA, Darmstadt, Germany; the 2018 Outstanding Researcher Award from Merck KGaA, Darmstadt, Germany; the 2017 Catalysis Club of Philadelphia Award for outstanding contributions in the area of catalysis; the 2015 ACS Industrial Chemistry Award; the 2015 IPMI Henry Alfred Award; the 2016 IIT Madras Distinguished Alumnus Award for Technology Innovation; the 2016 Chemical Research Society of India (CRSI) Medal; and the 2012 RSC Applied Catalysis Award and Medal. Dr. Colacot was responsible for developing a very successful homogeneous catalysis program at Johnson Matthey from 1995 to 2018. He holds an MBA degree from Penn State University and a Ph.D. degree in chemistry from IIT Madras. He has also carried out postdoctoral work in the U.S. and is a fellow of the Royal Society of Chemistry. He is also a visiting professor many leading universities internationally.
